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Storyline Missions
- Prologue - North Yankton, 9 years ago.
- Franklin and Lamar - Franklin and Lamar repossess two convertibles for an Armenian car dealer, Simeon.
- Repossession - Franklin and Lamar go to a shady part of Vespucci Beach to repo a bike for Simeon.
- Complications - Franklin heads to Rockford Hills to repo a car for Simeon.
- Father/Son - Jimmy gets in trouble with some gangsters and calls Michael for help.
- Chop - Lamar has a plan to make some extra cash.
- Marriage Counseling - Michael's marriage is on the rocks.
- Daddy's Little Girl - Michael and Jimmy pop out for some father/son bonding.
- Friend Request - Michael needs a job and turns to an old friend for help.
- The Long Stretch - Stretch has been released from prison, Lamar and Franklin take him out.
- The Good Husband (Family Mission) - Retrieve Amanda from shoplifting clothes and lose the cops.
- Casing the Jewel Store - Michael and Lester scout out a jeweler in Little Portola.
Loud Approach
Smart Approach
- Bugstars Equipment
- BZ Gas Grenades
- The Jewel Store Job - In need of money to pay Madrazo, Michael takes down a Rockford Hills Jewel Store with Franklin and a crew.
- Mr. Philips - Trevor has something to discuss with the Lost Motorcycle Club.
- Trevor Philips Industries - Trevor defends his cook house from a rival gang.
- Nervous Ron - Trevor and Ron intercept a weapons shipment.
- Crystal Maze - Trevor takes care of his business competition.
- Friends Reunited - Trevor sets off for Los Santos.
- Fame Or Shame - Tracey auditions for Fame or Shame.
- Dead Man Walking - Agent Dave Norton puts Michael in a difficult situation.
- Three's Company - Franklin and Trevor get roped into helping the FIB.
- By the Book - Michael and Trevor combine to locate a target for the FIB.
- Hood Safari - Franklin and Lamar show Trevor a typical South Los Santos neighborhood.
- Did Somebody Say Yoga? - Michael finds his inner peace.
- Scouting the Port - Trevor heads to the Port of LS to look for a job.
- Minisub - Get kitted up for the Merryweather Heist.
Offshore Approach
- Cargobob
- The Merryweather Heist - Trevor brings Michael and Franklin on board to steal a prototype on a Merryweather Security-protected ship in the Port of LS.
Freighter Approach
- The Merryweather Heist - Trevor brings Michael and Franklin on board to steal a prototype on a Merryweather Security-protected ship in the Port of LS.
- The Hotel Assassination - Lester asks Franklin to take down Brett Lowrey, CEO of Bilkinton Research, who is staying at the Von Crastenburg Hotel.
- Boiler Suits - Prep for an FIB operation.
- Masks - Prep for an FIB operation.
- Trash Truck - Prep for an FIB operation.
- Tow Truck - Prep for an FIB operation.
- Blitz Play - The FIB need Michael, Trevor and Franklin to rob an armored car.
- I Fought the Law... - Franklin steals a Cheetah and an Entity XF for Devin.
- Eye in the Sky - Franklin and Trevor locate a Z-Type for Devin.
- Mr. Richards - Michael gets his first job in the movie business.
- Caida Libre - Martin Madrazo needs a favor from Michael and Trevor.
- Deep Inside - Franklin boosts a JB 700 for Devin.
- Minor Turbulence - Trevor flies to intercept a cargo plane.
- Paleto Score Setup - Michael, Lester and Trevor check out a bank in Paleto Bay.
- Predator - Franklin, Trevor and Michael chase the O'Neil gang into the woods.
- Military Hardware - Prepare for the Paleto Score.
- The Paleto Score - Michael, Franklin and Trevor take a well-protected holding bank in sleepy fishing village, Paleto Bay.
- Derailed - Michael and Trevor stage a train robbery.
- Monkey Business - Michael, Trevor and Franklin help the FIB save the country.
- Hang Ten - Trevor and Wade leave Floyd and Debra's condo.
- Surveying the Score - Scope out the federal reserve in preparation for The Big Score.
- Bury the Hatchet - Trevor and Michael take a trip down memory lane.
- Pack Man - Franklin, Trevor and Lamar deliver Devin's cars to a drop-off point near Paleto Bay.
- Fresh Meat - Michael's world gets turned upside down.
- The Ballad of Rocco - Michael helps out Solomon Richards.
- Cleaning out the Bureau - The FIB wants you to do one last job.
- Architect's Plans - Prepare for the Bureau Raid.
Covert Approach
- Fire Truck
- The Bureau Raid - Having started a fire in the FIB headquarters, Michael and Franklin go in as firemen to perform a data theft.
Roof Approach
- The Bureau Raid - Michael and Franklin parachute onto the FIB headquarters to infiltrate their network and perform a data theft.
- The Wrap Up - Michael has a meeting with the FIB.
- Reuniting the Family - Michael begins to make amends with his family.
- Doting Dad (Family Mission) - Find Tracey's stalker and deal with him.
- Legal Trouble - Michael tries to protect the Movie Studio.
- Lamar Down - Lamar's in trouble and needs help.
- Meltdown - Michael attends the Meltdown premiere.
- Parenting 101 (Family Mission) - Rescue Jimmy from his kidnappers.
- Planning The Big Score - Set plans to rob the Union Depository.
Subtle Approach
- Stingers
- Gauntlet (1-3)
- The Big Score - Michael and Trevor con their way into the Union Depository and walk out with the gold reserves. Franklin organises the getaway.
Obvious Approach
- Sidetracked
- Driller
- The Big Score - While Michael causes a distraction at the Union Depository, Franklin and Trevor empty the vault of the gold reserves.
Ending A
- Something Sensible - Franklin has to make a choice.
Ending B
- The Time's Come - Franklin has to make a choice.
Ending C
- The Third Way - Michael, Franklin, and Trevor take down all their enemies: ambush FIB agents and Merryweather mercenaries at the foundry in Murrieta Heights, then target Wei Cheng, Stretch, Steve Haines and Devin Weston.
Lester's Assassinations
- The Hotel Assassination - Lester asks Franklin to take down Brett Lowrey, CEO of Bilkinton Research, who is staying at the Von Crastenburg Hotel.
- The Multi Target Assassination - Lester tasks Franklin to take down four corrupt jurors that are planning to throw a class-action lawsuit against Redwood Cigarettes.
- The Vice Assassination - Franklin must find and kill Jackson Skinner, the head of product development at Facade.
- The Bus Assassination - Lester asks Franklin to assassinate a man called Isaac Penny, who is about to take a controlling share in the Vapid Motor Company.
- The Construction Assassination - In the last Assassination, Lester tells Franklin to take down Enzo Bonelli, a mafia member turned real estate developer.
Collectables
- Epsilon Tracts (10)
- Ocean Hidden Packages (11)
- Altruist Hidden Packages (4)
- Letter Scraps (50)
- Spaceship Parts (50)
- Submarine Parts (30)
- Nuclear Waste (30)
- Stunt Jumps (50)
- Under the Bridge (50)
- Knife Flights (15)
- Rampages (5)
- Peyote Plants (27)
- Monkey Mosaics (50)
- Wildlife Photographs (20)
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